It seems impossible to create a game as Fallout 3, and meet the high expectations of all the eagerly waiting fans. Bethesda might be able to create fantastic worlds, but they're yet to prove (in my eyes) that they can create compelling gameplay other than exploring. But since half of Fallout was about exploring, the odds are looking pretty good. Now, let's hope they're going to implement the same open-ended gameplay as the original games, and give a bit more life to their characters than those featured in Oblivion.
This game is a bit different from the other ones on this list. Maybe that's mostly the reason why I'm looking forward to it. There's no story, no scripted events, or predefined ways of how to play the game. It's going to be a total sandbox where you can play for 15 minutes, or hours at a end. And since it's always fun to create things, and see the consequences of your creations, this is looking out to be something real interesting.
A game more focused on story and atmosphere, than running around and shooting things? This looks like it's going to turn out as a adventure game, which have been really sparse lately. Even though it's most likely going to be about going to point A to pick up object B and return it to position C, or activating script D when talking to NPC E, it atleast looks like your travelling means won't be restricted. Which means it's not going to become yet another walk down that very long corridor to complete the game, but actually giving you the choice of how to travel.